79.86 ± 1.07) – in the Group II, 21.96% (from 79.19
± 1.02 to 97.63 ± 2.03) – in the Group III (p1, p2,
p3 <0.05) and 14.22% (from 68.36 ± 0.35 to 79.7
± 1.04) - in the Comparison Group (p <0.05).
Also in the patients we treated there was a
positive dynamics of the scale Role Emotional
functioning (RE): by 27.37% (from 70.3 ± 1.16 to
96.8 ± 2.07) in patients of the Group I, by 12.36%
(from 73.26 ± 0.64 to 83.6 ± 1.35) – in the Group
II, by 15.7% (from 79.43 ± 0.38 to 94.3 ± 0.92 ) –
in the Group III (p1, p2, p3 <0.05) and 9.05% (from
69.3 ± 0.31 to 76.2 ± 0.82) - in patients of the
Comparison Group who received basic therapy (p
< 0.05).
Conclusions
Thus, the inclusion in the standard therapy of
gastroesophageal reflux disease in patients with its
development on the background of
undifferentiated connective tissue dysplasia of
magnesium lactate dihydrate in combination with
pyridoxine hydrochloride ("Magne -B6 ") and
calcium carbonate in combination with
cholecalciferol ("Calcium-D3 Nicomed")
contributed to a significant improvement in their
quality of life.
Conflict of interest
The authors declare that they have no conflict
of interest.
References
Alshammari, S. A., Alabdulkareem, A. M., Aloqeely,
K. M., Alhumud, M. I., Alghufaily, S. A., Al-
Dossare, Y. I., & Alrashdan, N. O.. (2020). The
Determinants of the Quality of Life of
Gastroesophageal Reflux Disease Patients
Attending King Saud University Medical City.
Cureus. https://doi.org/10.7759/cureus.9505
Gorczyca, R., Pardak, P., Pękala, A., & Filip, R..
(2019). Impact of gastroesophageal reflux
disease on the quality of life of Polish patients.
World Journal of Clinical Cases, 7(12), 1421–
1429.
https://doi.org/10.12998/wjcc.v7.i12.1421
Hill, C., Versluijs, Y., Furay, E., Reese-White, D.,
Holan, C., Alexander, J., Doggett, S., Ring, D.,
& Buckley, F. P.. (2020). Psychoemotional
factors and their influence on the quality of life
in patients with GERD. Surgical Endoscopy.
https://doi.org/10.1007/s00464-020-08145-8
Iudici, M., Irace, R., Riccardi, A., Cuomo, G.,
Vettori, S., & Valentini, G.. (2017). Longitudinal
analysis of quality of life in patients with
undifferentiated connective tissue diseases.
Patient Related Outcome Measures, Volume 8,
7–13. https://doi.org/10.2147/prom.s117767
Kulich, K. R., Madisch, A., Pacini, F., Piqué, J. M.,
Regula, J., Van Rensburg, C. J., Újszászy, L.,
Carlsson, J., Halling, K., & Wiklund, I. K.. (2008).
Reliability and validity of the Gastrointestinal
Symptom Rating Scale (GSRS) and Quality of
Life in Reflux and Dyspepsia (QOLRAD)
questionnaire in dyspepsia: A six-country study.
Health and Quality of Life Outcomes, 6(1), 12.
https://doi.org/10.1186/1477-7525-6-12
Romash, I., Mishchuk, V. (2019). Improvement of
Magnesium and Calcium Deficiency in
Patients with Gastroesophageal Reflux Disease
Associated with Undifferentiated Connective
Tissue Disease. Galician Medical Journal, 26(4).
https://doi.org/10.21802/gmj.2019.4.3
Romash, I. (2020). Disorders of social functioning
and quality of life in patients with
gastroesophageal reflux disease while
combined with undifferentiated connective
tissue dysplasia. Mental Health: Global
Challenges Journal, 3(1), 11–16.
https://doi.org/10.32437/mhgcj.v3i1.100
Romash, I.R., Vynnyk, M.I. (2020). Dynamics of
Quality of Life Indices in Case of Metabolic
Syndrome in Patients with Paranoid
Schizophrenia on the Background of Atypical
Neuroleptic Agents Application and
Improvement of Comorbidity. Ukrains’kyi visnyk
psykhonevrolohii. 27, 4 (101):62-67. doi:
https://doi.org/10.36927/2079-0325-V27-is4-
2019-11
Salome Satya Vani P et al., (2018). Assessment on
Patients Health Related Quality of Life
Associated With Gerd. Int J Recent Sci Res. 9(4),
pp. 25840-25845. DOI:
http://dx.doi.org/10.24327/ijrsr.2018.0904.1940
)
Yamasaki, T., Quan, S. F., & Fass, R. (2019). The
effect of sleep deficiency on esophageal acid
exposure of healthy controls and patients with
gastroesophageal reflux disease.
Neurogastroenterology and motility: the official
journal of the European Gastrointestinal Motility
Society, 31(12), e13705.
https://doi.org/10.1111/nmo.13705